MeSH

A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.

Year introduced: 1965(1963)

An 86-amino acid polypeptide, found in central and peripheral tissues, that displaces diazepam from the benzodiazepine recognition site on the gamma-aminobutyric acid receptor (RECEPTORS, GABA). It also binds medium- and long-chain acyl-CoA esters and serves as an acyl-CoA transporter. This peptide regulates lipid metabolism.

Year introduced: 2002

Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.

Year introduced: 1994

An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.

Year introduced: 1991(1977)

located on the outer mitochondrial membrane & enriched in the mitochondria of the steroidogenic cells; participates in the regulation of intramitochondrial cholesterol transport & may mediate the immediate action of steroidogenic hormones

a trypsin-sensitive peptide in pig that is a diazepam binding inhibitor with cholecystokinin releasing activity

a CYP3A isoform from rat liver microsomes; inhibited by mifepristone

drug metabolizing enzyme; demethylates diazepam

diazepam prodrug

amino acid sequence given in first source; major biologically active processing product of diazepam binding inhibitor

A benzodiazepine derivative used in the treatment of anxiety. It has sedative, muscle relaxant, and anticonvulsant properties. One of its metabolites is DIAZEPAM and one of its excretion products is OXAZEPAM.

Year introduced: 1991(1975)

A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.

Year introduced: 1984(1975)

A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.

Year introduced: 1991(1980)

An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.

Year introduced: 1988

amino acid sequence known

formed in base-catalyzed hydrolysis of diazepam; structure given in first source

shares sequence and structural similarities with the C-terminal domain of diazepam-binding inhibitor; possesses antibacterial activity; amino acid sequence given in first source; GenBank P01211

stimulates pregnenolone formation in mitochondria isolated from rat brain; amino acid sequence given in first source

structure given in first source; a high affinity ligand for diazepam-insensitive benzodiazepine receptors

a prothrombin complex concentrate; do not confuse with diazepam or streptokinase, which are both also known as Kabivitrum